abstract：:Recently, Shu-Yu Tai et al. reported that personal hair dye use increased risk of prostate cancer with a dose-response effect. Although hair dyes were identified as carcinogenic in animals and increased risk of some cancers among hairdressers, the existing epidemiological data did not support that personal hair dye us...

journal_title：BMC cancer

authors： Jiann BP

更新日期：2017-11-07 00:00:00

abstract：BACKGROUND:Many studies have combined sorafenib with transcatheter arterial chemoembolization (TACE) to treat patients with advanced hepatocellular carcinoma (HCC), but the results are disputable. Thus, we conducted this meta-analysis to assess the efficacy and safety of the combination treatment in patients with advan...

journal_title：BMC cancer

authors： Cai R,Song R,Pang P,Yan Y,Liao Y,Zhou C,Wang S,Zhou X,Wang H,Zhang H,Sun H,Ma H

更新日期：2017-11-06 00:00:00

abstract：BACKGROUND:Breast cancer is the most common invasive cancer among women. Currently, there are only a few models used for therapy selection, and they are often poor predictors of therapeutic response or take months to set up and assay. In this report, we introduce a microfluidic OrganoPlate® platform for extracellular m...

journal_title：BMC cancer

authors： Lanz HL,Saleh A,Kramer B,Cairns J,Ng CP,Yu J,Trietsch SJ,Hankemeier T,Joore J,Vulto P,Weinshilboum R,Wang L

更新日期：2017-11-02 00:00:00

abstract：BACKGROUND:The differentiation of pancreatic ductal adenocarcinoma (PDAC) could be associated with prognosis and may influence the choices of clinical management. No applicable methods could reliably predict the tumor differentiation preoperatively. Thus, the aim of this study was to compare the metabonomic profiling o...

journal_title：BMC cancer

authors： Wen S,Zhan B,Feng J,Hu W,Lin X,Bai J,Huang H

更新日期：2017-11-02 00:00:00

abstract：BACKGROUND:Quantifying the response of cell lines to drugs or other perturbagens is the cornerstone of pre-clinical drug development and pharmacogenomics as well as a means to study factors that contribute to sensitivity and resistance. In dividing cells, traditional metrics derived from dose-response curves such as IC...

journal_title：BMC cancer

authors： Clark NA,Hafner M,Kouril M,Williams EH,Muhlich JL,Pilarczyk M,Niepel M,Sorger PK,Medvedovic M

更新日期：2017-10-24 00:00:00

abstract：BACKGROUND:18F-FDG PET/CT could satisfactorily show pancreatic and extra-pancreatic lesions in AIP, which can be mistaken for pancreatic cancer (PC). This study aimed to identify 18F-FDG PET/CT findings that might differentiate AIP from PC. METHODS:FDG-PET/CT findings of 26 AIP and 40 PC patients were reviewed. Pancre...

journal_title：BMC cancer

authors： Zhang J,Jia G,Zuo C,Jia N,Wang H

更新日期：2017-10-23 00:00:00

abstract：BACKGROUND:Previous studies have found that polymorphisms of the DNA repair gene X-ray repair cross-complementing group 1(XRCC1) and environmental factors are both associated with an increased risk of stomach cancer, but no study has reported on the potential additive effect of these factors among Thai people. The aim ...

journal_title：BMC cancer

authors： Putthanachote N,Promthet S,Hurst C,Suwanrungruang K,Chopjitt P,Wiangnon S,Chen SL,Yen AM,Chen TH

更新日期：2017-10-11 00:00:00

abstract：BACKGROUND:Tumor invasion through a basement membrane is one of the earliest steps in metastasis, and growth factors, such as Epidermal Growth Factor (EGF) and Hepatocyte Growth Factor (HGF), stimulate this process in a majority of solid tumors. Basement membrane breakdown is one of the hallmarks of invasion; therefore...

journal_title：BMC cancer

authors： Dykes SS,Steffan JJ,Cardelli JA

更新日期：2017-10-04 00:00:00

abstract：BACKGROUND:There is evidence that some ovarian tumours evoke an immune response, which can be assessed by tumour infiltrating lymphocytes (TILs). To facilitate adoption of TILs as a clinical biomarker, a standardised method for their H&E visual evaluation has been validated in breast cancer. METHODS:We sought to inves...

journal_title：BMC cancer

authors： James FR,Jiminez-Linan M,Alsop J,Mack M,Song H,Brenton JD,Pharoah PDP,Ali HR

更新日期：2017-09-20 00:00:00

abstract：BACKGROUND:Uterine leiomyosarcoma (ULMS) is an aggressive form of soft tissue tumors. The molecular heterogeneity and pathogenesis of ULMS are not well understood. METHODS:Expression profiling data were used to determine the possibility and optimal number of ULMS molecular subtypes. Next, clinicopathological character...

journal_title：BMC cancer

authors： An Y,Wang S,Li S,Zhang L,Wang D,Wang H,Zhu S,Zhu W,Li Y,Chen W,Ji S,Guo X

更新日期：2017-09-11 00:00:00

abstract：BACKGROUND:Traditional beliefs of androgen's stimulating effects on the growth of prostate cancer (PCa) have been challenged in recent years. Our previous in vitro study indicated that physiological normal levels of androgens inhibited the proliferation of PCa cells. In this in vivo study, the ability of testosterone (...

journal_title：BMC cancer

authors： Song W,Soni V,Soni S,Khera M

更新日期：2017-09-07 00:00:00

abstract：BACKGROUND:Smoking is associated with an increased incidence of hormone receptor positive breast cancer. Data regarding worse breast cancer outcome in smokers are accumulating. Current literature regarding the impact of smoking on breast cancer characteristics is limited. We evaluated the impact of smoking on breast ca...

journal_title：BMC cancer

authors： Goldvaser H,Gal O,Rizel S,Hendler D,Neiman V,Shochat T,Sulkes A,Brenner B,Yerushalmi R

更新日期：2017-09-06 00:00:00

abstract：BACKGROUND:The numerous side effects of chemotherapy in patients with breast cancer are well known. However, the precise effects of chemotherapy on ovarian function in premenopausal women are poorly investigated. The patients are at risk of developing sexual hormone deficiency and impaired fertility. This prospective c...

journal_title：BMC cancer

authors： Wenners A,Grambach J,Koss J,Maass N,Jonat W,Schmutzler A,Mundhenke C

更新日期：2017-09-06 00:00:00

abstract：BACKGROUND:Genetic counselling and testing for Lynch syndrome (LS) have recently been introduced in several Latin America countries. We aimed to characterize the clinical, molecular and mismatch repair (MMR) variants spectrum of patients with suspected LS in Latin America. METHODS:Eleven LS hereditary cancer registrie...

journal_title：BMC cancer

authors： Rossi BM,Palmero EI,López-Kostner F,Sarroca C,Vaccaro CA,Spirandelli F,Ashton-Prolla P,Rodriguez Y,de Campos Reis Galvão H,Reis RM,Escremim de Paula A,Capochin Romagnolo LG,Alvarez K,Della Valle A,Neffa F,Kalfayan PG,Spir

更新日期：2017-09-05 00:00:00

abstract：BACKGROUND:Programmed cell death 1 (PD1) inhibitors have recently shown promising anti-cancer effects in a number of solid tumor types. A predictive biomarker to this class of drugs has not been clearly identified; however, overexpression of the PD1 ligand (PD-L1) has shown particular promise in lung adenocarcinoma. In...

journal_title：BMC cancer

authors： Tessier-Cloutier B,Kalloger SE,Al-Kandari M,Milne K,Gao D,Nelson BH,Renouf DJ,Sheffield BS,Schaeffer DF

更新日期：2017-09-05 00:00:00

abstract：BACKGROUND:Treatment of tonsil cancer, a subset of oropahryngeal cancer, varies between surgery and radiotherapy. Well-designed studies in tonsil cancer have been rare and it is still controversial which treatment is optimal. This study aimed to assess the outcome and failure patterns in tonsil cancer patients treated ...

journal_title：BMC cancer

authors： Song S,Wu HG,Lee CG,Keum KC,Kim MS,Ahn YC,Oh D,Park HJ,Lee SW,Park G,Moon SH,Cho KH,Kim YS,Won Y,Oh YT,Kim WT,Jeong JU

更新日期：2017-08-30 00:00:00

abstract：BACKGROUND:Recent studies suggested that cancer stem-like cells contribute to tumor vasculogenesis by differentiating into endothelial cells. However, such process is governed by still undefined mechanism. METHODS:At varying differentiation levels, three representative colon cancer cells were cultured in endothelial-i...

journal_title：BMC cancer

authors： Liu Z,Qi L,Li Y,Zhao X,Sun B

更新日期：2017-08-30 00:00:00

abstract：BACKGROUND:The EGFR and downstream signaling pathways play an important role in tumorigenesis in oral squamous cell carcinoma (OSCC). Gene copy number alteration is one mechanism for overexpressing the EGFR protein and was also demonstrated to be related to lymph node metastasis, tumor invasiveness and perineural invas...

journal_title：BMC cancer

authors： Huang SF,Chien HT,Cheng SD,Chuang WY,Liao CT,Wang HM

更新日期：2017-08-30 00:00:00

abstract：BACKGROUND:The variable prognosis in stage III cutaneous melanoma is partially due to unknown prognostic factors. Improved prognostic tools are required to define patients with an increased risk of developing metastatic disease who might benefit from adjuvant therapies. The aim was to examine if cellular immune markers...

journal_title：BMC cancer

authors： Falkenius J,Johansson H,Tuominen R,Frostvik Stolt M,Hansson J,Egyhazi Brage S

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:Venous thromboembolic events (VTE) are common in cancer patients and associated with higher mortality. In vivo thrombosis and anticoagulation might be involved in tumor growth and progression. We studied the association of warfarin and other anticoagulant use as antithrombotic medication and prostate cancer ...

journal_title：BMC cancer

authors： Kinnunen PTT,Murtola TJ,Talala K,Taari K,Tammela TLJ,Auvinen A

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:DNA methylation changes occurring in cancer cells are featured with both promoter CpG island hypermethylation and diffuse genomic hypomethylation. Long interspersed element-1 (LINE-1) is repeated in an interspersed manner with an estimated 500,000 copies per genome. LINE-1 has its CpG sites of the 5' untrans...

journal_title：BMC cancer

authors： Jeong S,Lee K,Wen X,Kim Y,Cho NY,Jang JJ,Kang GH

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:This study aimed to evaluate the long-term outcome and toxicities in patients with locoregionally advanced nasopharyngeal carcinoma (NPC) treated by concurrent chemoradiotherapy (CCRT) with/without adding cetuximab. METHODS:A total of 62 patients treated with CCRT plus cetuximab were matched with 124 patien...

journal_title：BMC cancer

authors： Li Y,Chen QY,Tang LQ,Liu LT,Guo SS,Guo L,Mo HY,Chen MY,Guo X,Cao KJ,Qian CN,Zeng MS,Bei JX,Shao JY,Sun Y,Tan J,Chen S,Ma J,Zhao C,Mai HQ

更新日期：2017-08-24 00:00:00

abstract：BACKGROUND:The aim of this study was to assess the feasibility and potential benefit of a brief psychosocial intervention based on cognitive-behavioral therapy performed in addition to early palliative care (PC) in the reduction of depressive symptoms among patients with advanced cancer. METHODS:An open-label randomiz...

journal_title：BMC cancer

authors： do Carmo TM,Paiva BSR,de Oliveira CZ,Nascimento MSA,Paiva CE

更新日期：2017-08-23 00:00:00

abstract：BACKGROUND:No scientific consensus has been reached on whether active tobacco smoking causes breast cancer. We examine the association between active smoking and breast cancer risk in Denmark, which has some of the highest smoking and breast cancer rates in women worldwide. METHODS:We used the data from a nationwide D...

journal_title：BMC cancer

authors： Andersen ZJ,Jørgensen JT,Grøn R,Brauner EV,Lynge E

更新日期：2017-08-22 00:00:00

abstract：BACKGROUND:Adoptive T-cell therapy relying on conventional T cells transduced with T-cell receptors (TCRs) or chimeric antigen receptors (CARs) has caused substantial tumor regression in several clinical trials. However, genetically engineered T cells have been associated with serious side-effects due to off-target tox...

journal_title：BMC cancer

authors： Harrer DC,Simon B,Fujii SI,Shimizu K,Uslu U,Schuler G,Gerer KF,Hoyer S,Dörrie J,Schaft N

更新日期：2017-08-17 00:00:00

abstract：BACKGROUND:Angipoietin-1 activation of the tyrosine kinase receptor Tek expressed mainly on endothelial cells leads to survival and stabilization of endothelial cells. Studies have shown that Angiopoietin-1 counteracts permeability induced by a number of stimuli. Here, we test the hypothesis that loss of Angiopoietin-1...

journal_title：BMC cancer

authors： Michael IP,Orebrand M,Lima M,Pereira B,Volpert O,Quaggin SE,Jeansson M

更新日期：2017-08-11 00:00:00

abstract：BACKGROUND:Patient-derived xenograft (PDX) models are important tools in precision medicine and for the development of targeted therapies to treat cancer patients. This study aimed to evaluate our precision medicine strategy that integrates genomic profiling and preclinical drug-screening platforms, in order to persona...

journal_title：BMC cancer

authors： Oh DY,Jung K,Song JY,Kim S,Shin S,Kwon YJ,Oh E,Park WY,Song SY,Choi YL

更新日期：2017-08-10 00:00:00

abstract：BACKGROUND:The lymphocytes played an important role in the natural history of cancer. The aim of this study was to explore the prognostic value of lymphocyte count and percentage for survival in advanced cancer patients receiving palliative care. METHODS:A retrospective review of clinicopathological data from 378 cons...

journal_title：BMC cancer

authors： Zhao W,Wang P,Jia H,Chen M,Gu X,Liu M,Zhang Z,Cheng W,Wu Z

更新日期：2017-08-02 00:00:00

abstract：BACKGROUND:Maintenance of quality of life is the primary goal during treatment of brain metastases (BM). This is a protocol of an ongoing phase III randomised multicentre study. This study aims to determine the exact additional palliative value of stereotactic radiosurgery (SRS) over whole brain radiotherapy (WBRT) in ...

journal_title：BMC cancer

authors： Zindler JD,Bruynzeel AME,Eekers DBP,Hurkmans CW,Swinnen A,Lambin P

更新日期：2017-07-25 00:00:00

abstract：BACKGROUND:BRCA1 and BRCA2 mutations explain approximately one-fifth of the inherited susceptibility in high-risk Finnish hereditary breast and ovarian cancer (HBOC) families. EMSY is located in the breast cancer-associated chromosomal region 11q13. The EMSY gene encodes a BRCA2-interacting protein that has been implic...

journal_title：BMC cancer

authors： Määttä KM,Nurminen R,Kankuri-Tammilehto M,Kallioniemi A,Laasanen SL,Schleutker J

更新日期：2017-07-24 00:00:00

abstract：BACKGROUND:Metformin is a biguanide oral hypoglycaemic agent commonly used for the treatment of type 2 diabetes mellitus. In addition to its anti-diabetic effect, metformin has also been associated with a reduced risk of cancer incidence of a number of solid tumours, including prostate cancer (PCa). However, the underl...

journal_title：BMC cancer

authors： Crawley D,Chandra A,Loda M,Gillett C,Cathcart P,Challacombe B,Cook G,Cahill D,Santa Olalla A,Cahill F,George G,Rudman S,Van Hemelrijck M

更新日期：2017-07-21 00:00:00

abstract：BACKGROUND:The 'common variant, common disease' model predicts that a significant component of hereditary breast cancer unexplained by pathogenic variants in moderate or high-penetrance genes is due to the cumulative effect of common risk variants in DNA (polygenic risk). Assessing a woman's breast cancer risk by testi...

journal_title：BMC cancer

authors： Yanes T,Meiser B,Young MA,Kaur R,Mitchell G,Barlow-Stewart K,Roscioli T,Halliday J,James P

更新日期：2017-07-18 00:00:00

abstract：BACKGROUND:This study aimed to evaluate the perioperative outcomes and prognostic impact of the consecutive steps of imaging, frailty assessment, and diagnostic laparoscopy (DLS) in patients with advanced epithelial ovarian cancer (EOC). METHODS:Patients diagnosed with EOC during 2012-2015 were analyzed retrospectivel...

journal_title：BMC cancer

authors： Eoh KJ,Yoon JW,Lee JY,Nam EJ,Kim S,Kim SW,Kim YT

更新日期：2017-07-12 00:00:00

abstract：BACKGROUND:CD133 (prominin-1) is widely believed to be a cancer stem cell marker in various solid tumor types, and CD133 has been correlated with tumor-initiating capacity. Recently, the nuclear location of CD133 expression in tumors has been discussed, but hepatocellular carcinoma (HCC) has not been included in these ...

journal_title：BMC cancer

authors： Chen YL,Lin PY,Ming YZ,Huang WC,Chen RF,Chen PM,Chu PY

更新日期：2017-07-07 00:00:00

abstract：BACKGROUND:Uridine 5'-diphosphate-glucuronosyltransferase 2B (UGT2B) genes code for enzymes that catalyze the clearance of testosterone, dihydrotestosterone (DHT), and DHT metabolites in the prostate basal and luminal tissue. The expression of the UGT2B15, UGT2B17, and UGT2B28 enzymes has not been evaluated in prostate...

journal_title：BMC cancer

authors： Grant DJ,Chen Z,Howard LE,Wiggins E,De Hoedt A,Vidal AC,Carney ST,Squires J,Magyar CE,Huang J,Freedland SJ

更新日期：2017-07-03 00:00:00

abstract：BACKGROUND:Patients with type 2 diabetes (T2D) are at increased risk for developing cancer. As approximately 8% of the world's population is living with T2D, even a slight increase in cancer risk could result in an enormous impact on the number of persons developing cancer. In addition, several glucose lowering drug cl...

journal_title：BMC cancer

authors： Schrijnders D,de Bock GH,Houweling ST,van Hateren KJJ,Groenier KH,Johnson JA,Bilo HJG,Kleefstra N,Landman GWD

更新日期：2017-06-23 00:00:00

abstract：BACKGROUND:Little information is available concerning how patient delay may be affected by mass disasters. The main objectives of the present study are to identify whether there was a post-disaster increase in the risk of experiencing patient delay among breast cancer patients in an area affected by the 2011 triple dis...

journal_title：BMC cancer

authors： Ozaki A,Nomura S,Leppold C,Tsubokura M,Tanimoto T,Yokota T,Saji S,Sawano T,Tsukada M,Morita T,Ochi S,Kato S,Kami M,Nemoto T,Kanazawa Y,Ohira H

更新日期：2017-06-19 00:00:00

abstract：BACKGROUND:To report a case of metastatic hepatocholangiocarcinoma to the vitreous and retina. CASE PRESENTATION:A 70-year-old male, who was recently diagnosed with hepatocholangiocarcinoma, was complaining of floaters in his right eye over the past 5 months and was referred to the Liverpool Ocular Oncology Centre. On...

journal_title：BMC cancer

authors： Praidou A,Jacob S,Irion L,Sivaraj R,Groenewald C,Coupland SE,Heimann H

更新日期：2017-06-19 00:00:00

abstract：BACKGROUND:Ovarian cancer is the leading cause of death among gynecologic diseases in Western countries. We have previously identified a miR-200-E-cadherin axis that plays an important role in ovarian inclusion cyst formation and tumor invasion. The purpose of this study was to determine if the miR-200 pathway is invol...

journal_title：BMC cancer

authors： Yang J,Zhou Y,Ng SK,Huang KC,Ni X,Choi PW,Hasselblatt K,Muto MG,Welch WR,Berkowitz RS,Ng SW

更新日期：2017-06-17 00:00:00

abstract：BACKGROUND:Patients undergoing surgery for esophageal cancer have a high risk for postoperative deterioration of lung function and pulmonary complications. This is partly due to one-lung ventilation during thoracotomy. This often accounts for prolonged stay on intensive care units, delayed postoperative reconvalescence...

journal_title：BMC cancer

authors： Pfirrmann D,Tug S,Brosteanu O,Mehdorn M,Busse M,Grimminger PP,Lordick F,Glatz T,Hoeppner J,Lang H,Simon P,Gockel I

更新日期：2017-06-14 00:00:00